Spontaneous germinal centers and autoimmunity
نویسندگان
چکیده
منابع مشابه
Targeting autoreactive germinal centers to curb autoimmunity
Autoimmune diseases have been on the rise in the past decades, particularly in Western societies [1]. Today, autoimmune disorders rank third on the list of most prevalent causes of morbidity and mortality in the Western world. Many autoimmune conditions, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are characterized by the presence of affinity-matured, class-switche...
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Models for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny. Indeed, recent studies have called several of their principal assumptions into question. In addition, the term germ...
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Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal centers, responding B cells selectively mutate the genes that encode their receptors for antigen. This process can change Ab affinity and specificity. The mutated cells t...
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Spontaneous germinal center (Spt-GC) B cells and follicular helper T cells generate high-affinity autoantibodies that are involved in the development of systemic lupus erythematosus. TLRs play a pivotal role in systemic lupus erythematosus pathogenesis. Although previous studies focused on the B cell-intrinsic role of TLR-MyD88 signaling on immune activation, autoantibody repertoire, and system...
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In the present study we demonstrate that all CD4(+) T cells in human tonsil expressing the Th2-selective receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) also 1) express high levels of CXCR5, and 2) display a transitional CD45RA/RO phenotype and consistently do not produce significant amounts of cytokines when immediately analyzed ex vivo. Hence, they represe...
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ژورنال
عنوان ژورنال: Autoimmunity
سال: 2017
ISSN: 0891-6934,1607-842X
DOI: 10.1080/08916934.2017.1280671